Genome wide study of gene regulation
نویسنده
چکیده
Gene expression patterns (motivation) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 Transcription factors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 Experimental discovery . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 Computational discovery . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 Discovered motifs have functional enrichments . . . . . . . . . . . . . . . . . . . . . . . . . . 2 Summary . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 microRNAs . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 The biology . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 Computational miRNA discovery . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 12 Drosophila genomes . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 Validation of the predicted miRNAs . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 Additional signatures of mature miRNAs . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 Prediction of binding sites . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5 Experimental approaches . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5 Computational approaches . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5 Phylogenetic footprinting . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5 Comparison with experiment . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5 Network level examination . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6
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